Marsia Gustiananda, S.Si., Ph.D.

Research Interest

  • T-cell epitopes mapping from pathogenic agents and cancer antigens using combine methods of immunoinformatic and in-vitro immunology assays to develop vaccines, immunotherapy, and diagnostics
  • T-cell based immune monitoring and diagnostics post vaccination and infection by SARS-CoV-2
  • T-cell epitopes cross reactivity between SARS-CoV-2 and common cold coronaviruses, live-attenuated vaccines, and other un-related pathogens
  • Identification of peptides binding to HLA alleles predominant in Indonesian population (i.e. HLA-A*24:07) to improve the accuracy of immunoinformatic prediction tools

Biography

After completing her training as an Analyst in Chemistry at a vocational senior high school in Bandung, Marsia Gustiananda advanced her chemical knowledge at the Department of Chemistry, Bandung Institute of Technology.

In her final year of B.Sc., she extended her studies to biochemistry and molecular biology and subsequently pursued her master’s degree at the John Curtin School of Medical Research, Australian National University, which was later upgraded into a Ph.D. degree. During her Ph.D., Marsia advanced her biochemical experience, learning peptide/protein science and mastering biophysical techniques to study the structure and function of prion protein repeat peptides. Marsia further developed her biochemistry and molecular biology skills in the research on yeast mutant resistance to atovaquone at the Eijkman Institute for Molecular Biology, before joining the Protein Chemistry group, Leiden Institute of Chemistry in the Netherlands where she developed a fluorescence-based histamine and cholesterol biosensor. In 2009, upon receiving the Small Grant Awards from the International Society for Infectious Diseases and Science and Technology Research Grants from Indonesia TORAY Science Foundation, Marsia started to build a platform of research on T-cell epitope mapping for avian influenza A virus H5N1, combining immunoinformatics and in-vitro T-cell immunology assays.  In 2012, she received a Fulbright Senior Research Fellowship Award that enabled her to join the research group of Prof. Hildebrand at the Oklahoma University Health Science Center to study peptide binding to HLA-A*24:07, one of the major HLA alleles found in the Indonesian population.  She is currently a faculty member of the Biomedicine Department and teaches subjects on immunology, cell signaling, cancer immunology, and virology.  She is a recipient of the Southeast Asia Europe Joint Funding Scheme for Research and Innovation Grant from KEMDIKBUDRISTEK to study cell-mediated immunity toward SARS-CoV-2 in the Indonesian population in collaboration with University Hospital Tuebingen and Faculty of Medicine Siriraj Hospital, Mahidol University.

Award and Industrial Collaboration

YearAwardSource
2019Best Flash Oral Presentations at Special Session: Bioinformatics in IndonesiaAPBioNET 18th International Conference on Bioinformatics
2019Scuola Superiore di Immunologia Ruggero Ceppellini full bursaries fellowshipsEFIS-EJI Ruggero Ceppellini Advanced School of Immunology, Italy
2012Fulbright Senior Research Fellowship Award 
2011Travel award from NTD@TRIAD to attend Neglected Tropical Disease Vaccine Design Toolkit and Training WorkshopsUniversity of Rhode Island, USA
2010Australian Endeavour Awards Postdoctoral Fellowship 

Research Activity and Highlighted Project

Year

Source

Title

Partners/Funding Agency

2025/2026

National

Peran andrografolida sebagai penghambat enzim Indoleamine 2,3-Dioxygenase untuk mengatasi resistensi cisplatin pada kanker serviks dan kanker paru-paru

DIKTI

2025/2026

Institution

Piper crocatum Endophytic Bacteria as A Novel Source of Antibiotic and Antibiofilm Agents

IPB University / i3L

2024/2025

Institution

Optimization and Validation of a Rapid and Cost-Effective RT-LAMP System for Enhanced Detection and Diagnostics of Dengue Virus Infection in Clinical Samples in Indonesia

Exeins Health Initiative / i3L

2023/2024

International

Characterization of T-cell Immunity to SARS-CoV-2 in the South East Asian and European Population (3rd Year)

Robert Bosch Center for Tumor Disease, Germany

Mahidol Unversity, Thailand / DIKTI (SEA-JFS)

2022/2023

International

Characterization of T-cell Immunity to SARS-CoV-2 in the South East Asian and European Population (2nd Year)

Robert Bosch Center for Tumor Disease, Germany

Mahidol Unversity, Thailand / DIKTI (SEA-JFS)

 

Selected Publication

Leonard, T. E., Liko, A., Gustiananda, M., Putra, A. B. N., Juanssilfero, A., & Hartrianti, P. (2023). Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer. International Journal of Biological Macromolecules, 225, 1–12. https://doi.org/10.1016/j.ijbiomac.2022.12.012

Gustiananda, M., Julietta, V., Hermawan, A., Febriana, G., Hermantara, R., Kristiani, L., Sidhartha, E., Sutejo, R., Agustriawan, D., Andarini, S., & Parikesit, A. A. (2022). Immunoinformatics Identification of the Conserved and Cross-Reactive T-Cell Epitopes of SARS-CoV-2 with Human Common Cold Coronaviruses, SARS-CoV, MERS-CoV and Live Attenuated Vaccines Presented by HLA Alleles of Indonesian Population. Viruses, 14, 2328. https://doi.org/10.3390/v14112328

Firmanda, A., Fahma, F., Syamsu, K., Cabral, J., Pletzer, D., & Gustiananda, M. (2022). Cellulose composites containing active constituents of coffee and tea: a prospective novel wound dressing. Materials Advances. https://doi.org/10.1039/d2ma00642a

Damai, F., Hermawan, A., Chrisdianto, M., Marcelina Julianto, N., & Martin, L. (2021). Immunoinformatics Analysis of Citrullinated Antigen as Potential Multi-peptide Lung Cancer Vaccine Candidates for Indonesian Population. https://doi.org/10.13140/RG.2.2.15887.51362

Intellectual Property Rights

Patent/Copyright

Title

Year

Copyright

PBMC Isolation Protocol: PBMC Isolation Using Ficoll-Paque Density Gradient Centrifugation

2022-2023

Copyright

In Vitro Cytoprotective Study On HaCaT Cells Against Pollution Models

2022-2023

Copyright

Immunoinformatics Module: Utilization of Immunoinformatics Approaches for Multi-epitope Vaccine Construct Design

2021-2022