Research Interest
Biography
Lidya Kristiani, S.Si., Ph.D. completed her Bachelor of Science at the Faculty of Biotechnology UNIKA ATMA JAYA in 2014 (cum laude). During her bachelor’s study, she was awarded the Korean Government Scholarship Program (KGSP) by the National Institute for International Education (NIIED) to immobilize and characterize Proteus vulgaris K80 lipase in the Catholic University of Korea. After finishing her bachelor’s study, she was awarded a master’s degree scholarship to study Integrated Biomedicine from Soonchunhyang Institute of Medi-Bio Science.
While studying, she was offered a transfer to the Ph.D. program in the same institute where she developed her passion for functional genomics. She received her doctorate in Integrated Biomedicine with honors in 2021. Her research focused on the development of a brand-new efficient chromatin interaction mapping technique called HS-Hi-C, which allows 3D mapping of genome organization from rare in vivo cell types. She then utilized this technique to examine the effect of age-associated loss of Lamin B1 protein on the overall genome organization and gene expression in mouse lens epithelial cells. Loss of Lamin B1 proteins has been associated with aging and various diseases such as cataracts and cancers. Her main interest is integrating functional genomic studies to unveil the molecular mechanism of diseases.
Award and Industrial Collaboration
Year | Award and Industrial Collaboration | Source |
2024/2025 | Evaluation of Cross Contamination of HPV Genotypes in Various Cell Lines by Novel Diagnostic Kit | PT Virtue Diagnostics Indonesia |
Research Activity and Highlighted Project
Year | Source | Title | Partners/Funding Agency |
2025/2026 | National | Peran andrografolida sebagai penghambat enzim Indoleamine 2,3-Dioxygenase untuk mengatasi resistensi cisplatin pada kanker serviks dan kanker paru-paru | DIKTI |
2025/2026 | Institution | Development of Coriander Extract-Based Dry Powder Inhaler to Overcome Cisplatin Resistance in Lung Cancer | Atma Jaya Catholic University / i3L |
2025/2026 | Institution | Exploring the Regenerative Effects of Various Pure Essential Oils on Human Skin Keratinocytes Under UVB-Induced Damage | i3L |
2025/2026 | Institution | An Investigation into the Wound Dressing Potentials of Biomembranes Synthesized from Indonesian Marine Macroalgae | Federation University / i3L |
2024/2025 | Institution | Exploring the Impact of Human Dermal Fibroblast Secretome on Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer | i3L |
Selected Publication
Kumar, S., Wu, C. C., Wulandari, F. S., Chiao, C. C., Ko, C. C., Lin, H. Y., Ngadio, J. L., Rebecca, C., Xuan, D. T. M., Solomon, D. D., Michael, M., Kristiani, L., Chuang, J. Y., Tsai, M. C., & Wang, C. Y. (2025). Integration of multi-omics and single-cell transcriptome reveals mitochondrial outer membrane protein-2 (MTX-2) as a prognostic biomarker and characterizes ubiquinone metabolism in lung adenocarcinoma. Journal of Cancer, 16(7), 2401–2420. https://doi.org/10.7150/jca.106902 |
Dearyza, S., Tanoto, J. P. W., Subrata, M. A., Febrian, T., Wibowo, K. M., Tjoa, O., Michael, M., Alexia, N., & Kristiani, L. (2025). Murraya koenigii extract potential as a herbal alternative therapeutic agent for inhibiting lung cancer cell migration via suppression of MMP-2 and MMP-9 activity. Notulae Scientia Biologicae, 17(4), 12725. https://doi.org/10.55779/nsb17412725 |
Kristiani, L., & Kim, Y. (2023). The Interplay between Oxidative Stress and the Nuclear Lamina Contributes to Laminopathies and Age-Related Diseases. Cells, 12(9), 1234. https://doi.org/10.3390/cells12091234 |
Gustiananda, M., Julietta, V., Hermawan, A., Febriana, G. G., Hermantara, R., Kristiani, L., Sidhartha, E., Sutejo, R., Agustriawan, D., Andarini, S., & Parikesit, A. A. (2022). Immunoinformatics Identification of the Conserved and Cross-Reactive T-Cell Epitopes of SARS-CoV-2 with Human Common Cold Coronaviruses, SARS-CoV, MERS-CoV and Live Attenuated Vaccines Presented by HLA Alleles of Indonesian Population. Viruses, 14(11), 2328. https://doi.org/10.3390/v14112328 |